Entity Central Index Key
Document And Entity Information [Abstract]
Document And Entity Information [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Accrued expenses and other current liabilities.
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Marketable securities
Marketable Securities Current
Accounts receivable
Accounts Receivable Gross Current
Prepaid expenses
Prepaid Expense Current
Other current assets
Other Assets Current
Total current assets
Assets Current
Marketable securities
Marketable Securities Noncurrent
Accounts receivable
Accounts Receivable Net Noncurrent
Property and equipment, net
Property Plant And Equipment Net
Operating lease right-of-use assets
Operating Lease Right Of Use Asset
Restricted cash
Restricted Cash And Cash Equivalents Noncurrent
Other assets
Other Assets Noncurrent
Total assets
Assets
Liabilities and Stockholders’ Equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities
Deferred revenue
Contract With Customer Liability Current
Operating lease liabilities
Operating Lease Liability Current
Total current liabilities
Liabilities Current
Deferred revenue
Contract With Customer Liability Noncurrent
Operating lease liabilities
Operating Lease Liability Noncurrent
Deferred rent
Deferred Rent Credit Noncurrent
Financing lease obligations
Finance Lease Liability Noncurrent
Other liabilities
Other Liabilities Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 6)
Commitments And Contingencies
Stockholders’ equity
Stockholders Equity [Abstract]
Preferred stock; $0.0001 par value; 10,000 shares authorized, and no shares issued and outstanding at March 31, 2019 and December 31, 2018
Preferred Stock Value
Common stock; $0.0001 par value; 100,000 shares authorized at March 31, 2019 and December 31, 2018; 36,611 and 36,120 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Interest income from licencing.
Income Statement [Abstract]
Revenues
Revenues [Abstract]
Revenues
Revenue From Contract With Customer Excluding Assessed Tax
Type of Revenue [Extensible List]
Type Of Revenue Extensible List
Operating Expenses
Costs And Expenses [Abstract]
Costs of revenues
Cost Of Revenue [Abstract]
Costs of revenues
Cost Of Goods And Services Sold
Type of Cost, Good or Service [Extensible List]
Type Of Cost Good Or Service Extensible List
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Other operating expenses
Other Operating Income Expense Net
Total operating expenses
Costs And Expenses
Income (loss) from operations
Operating Income Loss
Other Income
Nonoperating Income Expense [Abstract]
Interest income from licensing
Interest Income From Licencing
Investment income
Investment Income Net
Total other income
Nonoperating Income Expense
Income (loss) before income taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income Tax Benefit
Income Tax Expense Benefit
Net income (loss)
Net Income Loss
Other Comprehensive Income (Loss)
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Unrealized gain (loss) on available-for-sale securities, net of reclassifications and income tax expense
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Total other comprehensive income (loss)
Other Comprehensive Income Loss Net Of Tax
Comprehensive income (loss)
Comprehensive Income Net Of Tax
Net income (loss) applicable to common stockholders
Net Income Loss Available To Common Stockholders Basic
Net income (loss) per share:
Earnings Per Share Basic And Diluted [Abstract]
Basic
Earnings Per Share Basic
Diluted
Earnings Per Share Diluted
Weighted-average common shares outstanding:
Weighted Average Number Of Shares Outstanding [Abstract]
Basic
Weighted Average Number Of Shares Outstanding Basic
Diluted
Weighted Average Number Of Diluted Shares Outstanding
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional paid in capital [Member]
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Adjustments for New Accounting Pronouncements
Adjustments For New Accounting Pronouncements [Axis]
Type of Adoption
Type Of Adoption [Member]
ASU 2016-02 [Member]
Accounting Standards Update201602 [Member]
Accounting standards update 2018-02.
ASU 2018-02 [Member]
Accounting Standards Update201802 [Member]
ASU 2014-09 [Member]
Accounting Standards Update201409 [Member]
Statement [Line Items]
Statement [Line Items]
Balances
Balances (Shares)
Shares Outstanding
Adoption of ASU
New Accounting Pronouncement Or Change In Accounting Principle Effect Of Adoption Quantification
Exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Exercise of stock options, Shares
Stock Issued During Period Shares Stock Options Exercised
Issuance of common stock under employee stock purchase plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common stock under employee stock purchase plan, shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Unrealized gain (loss) on available-for-sale securities, net of reclassifications and income tax expense
Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax
Net income (loss)
Balances
Balances (Shares)
Imputed interest income from licensing.
Operating lease right- of-use assets.
Operating lease liabilities.
Increase decrease in deferred rent payable.
Statement Of Cash Flows [Abstract]
Cash flows from operating activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net income (loss)
Profit Loss
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Stock-based compensation expense
Share Based Compensation
Net amortization of premiums and accretion of discounts on marketable debt securities
Accretion Amortization Of Discounts And Premiums Investments
Depreciation and amortization
Depreciation And Amortization
Imputed interest income from licensing
Imputed Interest Income From Licensing
Other non-cash adjustments
Other Noncash Income Expense
Changes in operating assets and liabilities
Increase Decrease In Operating Capital [Abstract]
Accounts receivable
Increase Decrease In Accounts Receivable
Prepaid expenses
Increase Decrease In Prepaid Expense
Other current assets
Increase Decrease In Other Current Assets
Operating lease right-of-use assets
Increase Decrease In Operating Lease Right Of Use Assets
Other assets
Increase Decrease In Other Operating Assets
Accounts payable
Increase Decrease In Accounts Payable Trade
Accrued expenses and other current liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Deferred rent
Increase Decrease In Deferred Rent Payable
Other liabilities
Increase Decrease In Other Operating Liabilities
Net cash provided by (used in) operating activities
Net Cash Provided By Used In Operating Activities
Cash flows from investing activities
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of marketable securities
Payments To Acquire Marketable Securities
Maturities of marketable securities
Proceeds From Sale And Maturity Of Marketable Securities
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Net cash provided by (used in) investing activities
Net Cash Provided By Used In Investing Activities
Cash flows from financing activities
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from exercise of stock options
Proceeds From Stock Options Exercised
Proceeds from issuance of common stock under employee stock purchase plan
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase (decrease) in cash and cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash and cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents [Abstract]
Beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
End of period
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of Business
Nature Of Operations
Accounting Policies [Abstract]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Investments Debt And Equity Securities [Abstract]
Marketable Securities
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Instruments
Fair Value Disclosures [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
License agreement revenue recognition.
License Agreement Revenue Recognition [Abstract]
License Agreement Revenue Recognition [Abstract]
License Revenue
License Agreement Revenue Recognition [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Related Party Transactions [Abstract]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Earnings Per Share [Abstract]
Net Income (Loss) Per Share
Earnings Per Share [Text Block]
Payables And Accruals [Abstract]
Supplemental Disclosures
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Basis of Presentation and Principles of Consolidation
Basis Of Accounting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Marketable Securities
Marketable Securities Policy
Leases
Lessee Leases Policy [Text Block]
Fair Value of Financial Instruments
Fair Value Of Financial Instruments Policy
Net Income (Loss) Per Share
Earnings Per Share Policy [Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Schedule of cash and cash equivalents and restricted cash.
Summary of Reconciliation of Cash and Cash Equivalents and Restricted Cash
Schedule Of Cash And Cash Equivalents And Restricted Cash Table [Text Block]
Summary of Company Marketable Securities
Debt Securities Available For Sale Table [Text Block]
Summary of Fair Values and Unrealized Losses of Marketable Securities Held by the Company in an Unrealized Loss Position for Less Than 12 months and 12 Months or Greater
Debt Securities Available For Sale Unrealized Loss Position Fair Value Table [Text Block]
Schedule of Fair Value of Cash Equivalents and Marketable Securities
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Schedule of Property and Equipment
Property Plant And Equipment [Text Block]
Summary of lease costs and supplemental cash flow information of operating leases.
Summary of Lease Costs and Supplemental Cash Flow Information of Operating Leases
Summary Of Lease Costs And Supplemental Cash Flow Information Of Operating Leases Table [Text Block]
Schedule of lessee operating lease weighted-average remaining lease term and weighted-average discount rate.
Weighted-Average Remaining Lease Term and Weighted-Average Discount Rate of Operating Leases
Schedule Of Lessee Operating Lease Weighted Average Remaining Lease Term And Weighted Average Discount Rate
Reconciliation of Undiscounted Future Minimum Lease Payments Remaining Under 9800 Medical Center Drive Lease and Other Operating Leases
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Future Minimum Lease Payments Under Topic 840 for 9800 Medical Center Drive Lease and Other Operating Leases
Schedule Of Future Minimum Rental Payments For Operating Leases Table [Text Block]
Summary of changes in receivables and contract assets and contract liabilities.
Summary of Changes in Balances of Receivables, Contract Assets and Contract Liabilities
Summary Of Changes In Receivables And Contract Assets And Contract Liabilities Table [Text Block]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two Thousand Fourteen And Two Thousand Fifteen Equity Incentive Plan [Member]
2014 and 2015 Equity Incentive Plan [Member]
Two Thousand Fourteen And Two Thousand Fifteen Equity Incentive Plan [Member]
Stock-Based Compensation Expense by Award Type
Disclosure Of Share Based Compensation Arrangements By Share Based Payment Award [Text Block]
Stock-Based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Summary of Stock Option Activity
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Unvested RSUs Activity Under 2015 Plan
Schedule Of Nonvested Restricted Stock Units Activity Table [Text Block]
Computations of Basic and Diluted Net Income (Loss) Per Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Schedules for Computation of Diluted Weighted-Average Shares Outstanding
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedules of Accrued Expenses and Other Current Liabilities
Schedule Of Accounts Payable And Accrued Liabilities Table [Text Block]
Cash, cash equivalents and marketable securities
Cash Cash Equivalents And Short Term Investments
Total cash and cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Significant Accounting Policies.
Significant Accounting Policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Restatement
Restatement [Axis]
Restatement
Restatement [Domain]
Restatement Adjustment [Member]
Restatement Adjustment [Member]
Name of Property
Real Estate And Accumulated Depreciation Description Of Property [Axis]
Name of Property
Real Estate And Accumulated Depreciation Name Of Property [Domain]
Nine Thousand Eight Hundred Medical Center Drive.
9800 Medical Center Drive Lease [Member]
Nine Thousand Eight Hundred Medical Center Drive [Member]
Range
Range [Axis]
Range
Range [Member]
Maximum [Member]
Maximum [Member]
Minimum [Member]
Minimum [Member]
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Impairment of available-for-sale securities deemed to be other-than-temporary
Other Than Temporary Impairment Loss Debt Securities Available For Sale Recognized In Earnings
Operating lease liabilities
Operating Lease Liability
Financing lease obligation
Amount of increase (decrease) in accumulated other comprehensive income (AOCI) for reclassification to retained earnings of tax effect from remeasurement of deferred tax pursuant to Tax Cuts and Jobs Act.
Reclassification of stranded tax effects of unrealized gains and losses on available-for-sale securities from accumulated other comprehensive loss to accumulated deficit
Tax Cuts And Jobs Act Reclassification From A O C I To Retained Earnings Tax Effect
Schedule Of Available For Sale Securities [Table]
Schedule Of Available For Sale Securities [Table]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
U.S. Government and Federal Agency Securities [Member]
U S Government Corporations And Agencies Securities [Member]
Certificates of Deposit [Member]
Certificates Of Deposit [Member]
Corporate Bonds [Member]
Corporate Bond Securities [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Unrealized Gains
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Unrealized Losses
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Available For Sale Securities Debt Securities
Available for sale debt securities remaining maturities greater than three years.
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Investment Income [Member]
Investment Income [Member]
Available for sale securities remaining maturities greater than three years
Available For Sale Debt Securities Remaining Maturities Greater Than Three Years
Unrealized gains (losses) on available-for-sale securities, before tax
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Before Tax
Unrealized gains (losses) on available-for-sale securities, income tax expense
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax
Net realized gains or losses available for sale securities
Debt Securities Available For Sale Realized Gain Loss
Less than 12 Months, Fair Value
Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months
Less than 12 Months, Unrealized Losses
Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months Accumulated Loss
12 Months or Greater, Fair Value
Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer
12 Months or Greater, Unrealized Losses
Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer Accumulated Loss
Total, Fair Value
Debt Securities Available For Sale Unrealized Loss Position
Total, Unrealized Losses
Debt Securities Available For Sale Unrealized Loss Position Accumulated Loss
Less than 12 Months, Fair Value
Available For Sale Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value
12 Months or Greater, Fair Value
Available For Sale Securities Continuous Unrealized Loss Position Twelve Months Or Longer Fair Value
Total, Fair Value
Available For Sale Securities Continuous Unrealized Loss Position Fair Value
Number of investment grade fixed income security
Debt Securities Available For Sale Unrealized Loss Position Number Of Positions
Other-than-temporary impaired
Other Than Temporary Impairment Loss Debt Securities Available For Sale
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Quoted Prices in Active Markets (Level 1) [Member]
Fair Value Inputs Level1 [Member]
Significant Other Observable Inputs (Level 2) [Member]
Fair Value Inputs Level2 [Member]
Significant Unobservable Inputs (Level 3) [Member]
Fair Value Inputs Level3 [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Mutual Funds [Member]
Money Market Funds [Member]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Cash Equivalents [Member]
Cash Equivalents [Member]
U.S. Government and Federal Agency Securities [Member]
U S Government Agencies Debt Securities [Member]
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
Cash equivalents and marketable securities.
Cash Equivalents and Marketable Securities [Member]
Cash Equivalents And Marketable Securities [Member]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Cash equivalents:
Cash And Cash Equivalents [Abstract]
Total cash equivalents
Cash And Cash Equivalents Fair Value Disclosure
Marketable securities:
Marketable Securities [Abstract]
Total cash equivalents and marketable securities
Assets Fair Value Disclosure
Fair value hierarchy level 1 to level 2 transfers amount
Fair Value Assets Level1 To Level2 Transfers Amount
Fair value hierarchy level 2 to level 1 transfers amount
Fair Value Assets Level2 To Level1 Transfers Amount
Non-marketable equity securities had carrying value.
Remeasurements or impairment losses on non-marketable equity securities.
Non-marketable equity securities
Non Marketable Equity Securities Carrying Value
Remeasurements or impairment losses on non-marketable equity securities
Remeasurements Or Impairment Losses On Non Marketable Equity Securities
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment, Type
Property Plant And Equipment By Type [Axis]
Property, Plant and Equipment, Type
Property Plant And Equipment Type [Domain]
Lab Equipment [Member]
Equipment [Member]
Computer Equipment and Software [Member]
Computer Equipment [Member]
Furniture and Fixtures [Member]
Furniture And Fixtures [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Construction in Progress [Member]
Construction In Progress [Member]
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Total property and equipment
Property Plant And Equipment Gross
Accumulated depreciation and amortization
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Lessee, operating lease, number of square feet to be constructed.
Tenant improvement allowance to be received.
Minimum required lease term to use optional termination of lease.
Percentage of early termination fee.
Term of required base rent to be paid as termination fee.
Lessee, operating lease, periodic payment term, after the commencement.
Lessee, operating lease, frequency of periodic payment.
Other Commitments [Table]
Other Commitments [Table]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Rockville, Maryland [Member]
MARYLAND
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Nine thousand seven hundred twelve Medical Center Drive.
9712 Medical Center Drive [Member]
Nine Thousand Seven Hundred Twelve Medical Center Drive [Member]
Nine thousand six hundred Blackwell Road.
9600 Blackwell Road [Member]
Nine Thousand Six Hundred Blackwell Road [Member]
Maryland and New York.
Rockville, Maryland and New York, New York [Member]
Maryland And New York [Member]
New York [Member]
NEW YORK
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
University of Pennsylvania.
University of Pennsylvania [Member]
University Of Pennsylvania [Member]
Litigation Case
Litigation Case [Axis]
Litigation Case
Litigation Case Type [Domain]
European patent office proceeding.
European Patent Office Proceeding [Member]
European Patent Office Proceeding [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Number of square feet to be constructed
Lessee Operating Lease Number Of Square Feet To Be Constructed
Construction completion, description
Lessee Operating Lease Lease Not Yet Commenced Description
Lease term, from the delivery of leased premises
Lessee Operating Lease Lease Not Yet Commenced Term Of Contract1
Tenant improvement allowance entitled to received
Tenant Improvement Allowance To Be Received
Lease not yet commenced, option to extend the lease
Lessee Operating Lease Lease Not Yet Commenced Existence Of Option To Extend
Lease not yet commenced, additional lease term
Lessee Operating Lease Lease Not Yet Commenced Renewal Term1
Lease not yet commenced, option to terminate the lease
Lessee Operating Lease Lease Not Yet Commenced Existence Of Option To Terminate
Lease not yet commenced, option to terminate the lease, description
Lessee Operating Lease Lease Not Yet Commenced Option To Terminate
Minimum release term for option to terminate
Minimum Required Lease Term To Use Optional Termination Of Lease
Percentage of early termination fee
Percentage Of Early Termination Fee
Term of required base rent to be paid as termination fee
Term Of Required Base Rent To Be Paid As Termination Fee
Frequency of periodic payment
Lessee Operating Lease Frequency Of Periodic Payment
Periodic payment term, from the delivery of leased premises
Lessee Operating Lease Periodic Payment Term After The Commencement
Letters of credit
Letters Of Credit Outstanding Amount
Payment to landlord
Payments For Tenant Improvements
Lessee, operating lease, lease not yet commenced, additional area leased.
Change in tenant improvement allowance.
Lessee, operating lease increased on future rent.
Number of square feet to be constructed
Lessee Operating Lease Lease Not Yet Commenced Additional Area Leased
Change in tenant improvement allowance
Change In Tenant Improvement Allowance
Increased on future rent
Lessee Operating Lease Increased On Future Rent
Lease commenced date.
Lease term commenced date
Lease Commenced Date
Lease term
Lessee Operating Lease Description
Operating lease, existense of option to extend the lease
Lessee Operating Lease Existence Of Option To Extend
Additional lease term under option to extend
Lessee Operating Lease Renewal Term
Tenant improvement allowance received
Payments For Proceeds From Tenant Allowance
Lease payments commencement Period.
Required period to terminate lease after commencement period.
Lease period
Lessee Operating Lease Term Of Contract
Lease expiration date
Lease Expiration Date1
Monthly lease payments commencement period
Lease Payments Commencement Period
Required period to terminate lease after commencement period
Required Period To Terminate Lease After Commencement Period
Operating lease expiration year.
Operating leases expiration year
Operating Lease Expiration Year
Leases [Abstract]
Operating lease cost
Operating Lease Cost
Variable lease cost
Variable Lease Cost
Total lease cost
Lease Cost
Cash paid for amounts included in the measurement of operating lease liabilities
Operating Lease Payments
Right-of-use assets acquired through operating lease liabilities
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Weighted-average remaining lease term (years)
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate
Operating Lease Weighted Average Discount Rate Percent
Lessee Lease Description [Table]
Lessee Lease Description [Table]
Other properties held under operating leases.
Other Operating leases [Member]
Other Properties Held Under Operating Leases [Member]
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Undiscounted future minimum lease payments:
Operating Lease Liabilities Payments Due [Abstract]
2019 (remainder of year)
Lessee Operating Lease Liability Payments Remainder Of Fiscal Year
2020
Lessee Operating Lease Liability Payments Due Year Two
2021
Lessee Operating Lease Liability Payments Due Year Three
2022
Lessee Operating Lease Liability Payments Due Year Four
2023
Lessee Operating Lease Liability Payments Due Year Five
Thereafter
Lessee Operating Lease Liability Payments Due After Year Five
Total undiscounted future minimum lease payments
Lessee Operating Lease Liability Payments Due
Amount representing imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Total operating lease liabilities
Current portion of operating lease liabilities
Operating lease liabilities, non-current
Type of Arrangement and Non-arrangement Transactions
Type Of Arrangement [Axis]
Arrangements and Non-arrangement Transactions
Arrangements And Nonarrangement Transactions [Member]
Other operating leases.
Other Operating leases [Member]
Other Operating Leases [Member]
2019
Operating Leases Future Minimum Payments Remainder Of Fiscal Year
2020
Operating Leases Future Minimum Payments Due In Two Years
2021
Operating Leases Future Minimum Payments Due In Three Years
2022
Operating Leases Future Minimum Payments Due In Four Years
2023
Operating Leases Future Minimum Payments Due In Five Years
Thereafter
Operating Leases Future Minimum Payments Due Thereafter
Total minimum lease payments
Operating Leases Future Minimum Payments Due
Upfront fee payable.
Upfront fee, milestone fees
Upfront Fee Payable
Liability related to third party opposition
Loss Contingency Accrual At Carrying Value
Number of development partnered product candidates.
Number of technology licensees.
License revenue.
License revenue.
License Revenue [Table]
License Revenue [Table]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
NAV technology licensees.
NAV Technology Licensees [Member]
N A V Technology Licensees [Member]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
NAV technology platform.
NAV Technology Platform [Member]
N A V Technology Platform [Member]
January 2018 Amendment Agreement.
January 2018 Amendment Agreement [Member]
January Two Zero One Eight Amendment Agreement [Member]
AveXis, Inc.
AveXis, Inc. [Member]
Ave Xis Incorporation [Member]
License agreement.
License Agreement [Member]
License Agreement [Member]
License [Member]
License [Member]
November two thousand eighteen license agreement.
November 2018 License Agreement [Member]
November Two Thousand Eighteen License Agreement [Member]
Abeona Therapeutics Inc
Abeona Therapeutics Inc. [Member]
Abeona Therapeutics Incorporation [Member]
March 2014 License Agreement.
March 2014 License Agreement [Member]
March Two Zero One Four License Agreement [Member]
First Anniversary.
First Anniversary [Member]
First Anniversary [Member]
Second Anniversary.
Second Anniversary [Member]
Second Anniversary [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others By Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Research And Development Arrangement Contract To Perform For Others Type [Domain]
Sales based milestones.
Share-based Milestone [Member]
Sales Based Milestones [Member]
License Revenue [Line Items]
License Revenue [Line Items]
Number of development partnered product candidates
Number Of Development Partnered Product Candidates
Number of technology licensees
Number Of Technology Licensees
Milestone fee payments upon commencement of clinical trials.
Milestone fee payments upon submission of regulatory approval filings.
Milestone fee payments upon approval of commercial products.
Milestone fee payments upon achievement of specified sales targets.
Milestone payment upon commencement of clinical trials in humans
Milestone Fee Payments Upon Commencement Of Clinical Trials
Milestone payment upon submission of regulatory approval filings
Milestone Fee Payments Upon Submission Of Regulatory Approval Filings
Milestone payment upon approval of commercial products by regulatory agencies
Milestone Fee Payments Upon Approval Of Commercial Products
Milestone payment upon achievement of specified sales targets for licensed products
Milestone Fee Payments Upon Achievement Of Specified Sales Targets
Receivables and contract assets.
Increase (decrease) in accounts receivable current and noncurrent.
Receivables and contract assets:
Receivables And Contract Assets [Abstract]
Accounts receivable, current and non-current, Balance at Beginning of Period
Accounts Receivable Net
Accounts receivable, current and non-current, Net Additions (Deductions)
Increase Decrease In Accounts Receivable Current And Noncurrent
Accounts receivable, current and non-current, Balance at End of Period
Increase (decrease) in contract with customer asset current.
Contract assets, Balance at Beginning of Period
Contract With Customer Asset Net Current
Contract assets, Net Additions (Deductions)
Increase Decrease In Contract With Customer Asset Current
Contract assets, Balance at End of Period
Contract liabilities:
Contract With Customer Liability [Abstract]
Deferred revenue, current and non-current, Balance at Beginning of Period
Contract With Customer Liability
Changes in deferred revenue
Increase Decrease In Contract With Customer Liability
Deferred revenue, current and non-current, Balance at End of Period
Accounts receivable
Accounts Receivable Gross
Deferred revenue, current and non-current
License revenue
Contract With Customer Performance Obligation Satisfied In Previous Period
Impirment losses on receivables or contract assets
Capitalized Contract Cost Impairment Loss
Total current and non-current accounts receivable
Billed to customers
Billed Contract Receivables
Billable to customers in future periods
Unbilled Contracts Receivable
Upfront license fee paid.
Milestone fee payments upon achievement of various development and commercialization.
Up-front fee paid
Upfront License Fee Paid
Milestone fee payments upon achievement of various development and commercialization
Milestone Fee Payments Upon Achievement Of Various Development And Commercialization
License agreement period.
License agreement period
License Agreement Period
License agreement amendment date.
License agreement amendment date
License Agreement Amendment Date
License fees.
Milestone payments.
Unpaid milestone payments.
License fee
License Fees
Milestone payment
Milestone Payments
Sales-based milestone payment unpaid in the event of change of control
Unpaid Milestone Payments
License fees received
Proceeds From License Fees Received
Transaction price of license.
Payments for remaining development milestones.
Transaction price of license
Transaction Price Of License
Payments for remaining development milestones
Payments For Remaining Development Milestones
Sales-based milestone payment exclude transaction price.
Consideration payment due period one.
Consideration payment due period two.
Increase in transaction price of license.
Transaction price description
Revenue Information Used To Determine Transaction Price
Increase in transaction price of license
Increase In Transaction Price Of License
Sales-based milestone payment exclude transaction price
Sales Based Milestone Payment Exclude Transaction Price
Payments due from related party
Due From Related Parties
Consideration payment due period one
Consideration Payment Due Period One
Consideration payment due period two
Consideration Payment Due Period Two
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Start Date [Axis]
Revenue, remaining performance obligation, expected timing of satisfaction, period
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Period1
Revenue
Accounts receivable, current
Accounts receivable, non -current
Accounts Receivable Gross Noncurrent
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Two Thousand And Fifteen Equity Incentive Plan [Member]
2015 Equity Incentive Plan [Member]
Two Thousand And Fifteen Equity Incentive Plan [Member]
2015 Employee Stock Purchase Plan.
2015 Employee Stock Purchase Plan [Member]
Two Thousand Fifteen Employee Stock Purchase Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Additional shares to be issued
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Common stock shares authorized for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Shares available for future grants
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Equity [Abstract]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Employee Stock Purchase Plan [Member]
Employee Stock [Member]
Award Type
Award Type [Axis]
Equity Award
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Option [Member]
Employee Stock Option [Member]
Restricted Stock Units [Member]
Restricted Stock Units R S U [Member]
Stock-based compensation expense
Allocated Share Based Compensation Expense
Unrecognized stock-based compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized
Unrecognized stock-based compensation, weighted-average period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Research and Development Costs [Member]
Research And Development Expense [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Shares Outstanding, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Shares, Exercised
Shares, Cancelled or forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Shares Outstanding, Ending Balance
Shares, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Shares, Vested and expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Weighted-average Exercise Price Outstanding, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted-average Exercise Price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Cancelled or forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Outstanding, Ending Balance
Weighted-average Exercise Price, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted-average Exercise Price, Vested and expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Weighted-average Remaining Contractual Life (Years) Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted-average Remaining Contractual Life (Years), Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Weighted-average Remaining Contractual Life (Years), Vested and expected to vest
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Aggregate Intrinsic Value Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Aggregate Intrinsic Value, Vested and expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Weighted-average fair values of options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Total intrinsic value of options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Shares Unvested, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Shares, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Shares Unvested, Ending Balance
Weighted-average Grant Date Fair Value, Unvested Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value, Unvested Ending Balance
Common stock shares issued to participants
Share Based Compensation Arrangement By Share Based Payment Award Shares Issued In Period
Income tax disclosure.
Income tax disclosure.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Balance Sheet Location
Balance Sheet Location [Axis]
Balance Sheet Location
Balance Sheet Location [Domain]
Accrued expenses and other current liabilities.
Accrued Expenses and Other Current Liabilities [Member]
Accrued Expenses And Other Current Liabilities [Member]
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Income tax benefit
Accrued income tax provision
Accrued Income Taxes Current
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
FOXKISER limited liability partnership.
FOXKISER,LLP [Member]
F O X K I S E R Limited Liability Partnership [Member]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
Service Agreements [Member]
Service Agreements [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Related party transaction expense
Related Party Transaction Expenses From Transactions With Related Party
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Employee stock purchase plan.
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Basic net income (loss) per share:
Earnings Per Share Basic [Abstract]
Shares used in computation:
Earnings Per Share Basic Other Disclosures [Abstract]
Weighted-average common shares outstanding
Basic net income (loss) per share
Diluted net income (loss) per share:
Earnings Per Share Diluted [Abstract]
Net income (loss) applicable to common stockholders
Net Income Loss Available To Common Stockholders Diluted
Shares used in computation:
Earnings Per Share Diluted Other Disclosures [Abstract]
Weighted-average diluted common shares
Diluted net income (loss) per share
Stock Options Issued and Outstanding [Member]
Unvested Restricted Stock Units Outstanding [Member]
Anti-dilutive securities excluded from computation of diluted weighted average shares outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Accrued external research and development expenses.
Accrued licensing costs.
Accrued external general and administrative expenses,
Accrued purchases of property and equipment.
Accrued external research and development expenses
Accrued External Research And Development Expenses
Accrued personnel costs
Employee Related Liabilities Current
Accrued income taxes payable
Accrued licensing costs
Accrued Licensing Costs
Accrued external general and administrative expenses
Accrued External General And Administrative Expenses
Accrued purchases of property and equipment
Accrued Purchases Of Property And Equipment
Other accrued expenses and current liabilities
Other Accrued Liabilities Current
Accrued expenses and other current liabilities