Entity Central Index Key Cover [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Entity Interactive Data Current Entity Interactive Data Current Title of 12(b) Security Security12b Title Security Exchange Name Security Exchange Name Entity File Number Entity File Number Entity Incorporation, State or Country Code Entity Incorporation State Country Code Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address Address Line1 Entity Address, Address Line Two Entity Address Address Line2 Entity Address, City or Town Entity Address City Or Town Entity Address, State or Province Entity Address State Or Province Entity Address, Postal Zip Code Entity Address Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Document Annual Report Document Annual Report Document Transition Report Document Transition Report Documents Incorporated by Reference Documents Incorporated By Reference [Text Block] Accrued expenses and other current liabilities. Statement Of Financial Position [Abstract] Assets Assets [Abstract] Current assets Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Marketable securities Marketable Securities Current Accounts receivable Accounts Receivable Gross Current Prepaid expenses Prepaid Expense Current Other current assets Other Assets Current Total current assets Assets Current Marketable securities Marketable Securities Noncurrent Accounts receivable Accounts Receivable Net Noncurrent Property and equipment, net Property Plant And Equipment Net Operating lease right-of-use assets Operating Lease Right Of Use Asset Restricted cash Restricted Cash And Cash Equivalents Noncurrent Other assets Other Assets Noncurrent Total assets Assets Liabilities and Stockholders’ Equity Liabilities And Stockholders Equity [Abstract] Current liabilities Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Expenses And Other Current Liabilities Deferred revenue Contract With Customer Liability Current Operating lease liabilities Operating Lease Liability Current Total current liabilities Liabilities Current Deferred revenue Contract With Customer Liability Noncurrent Operating lease liabilities Operating Lease Liability Noncurrent Deferred rent Deferred Rent Credit Noncurrent Financing lease obligations Finance Lease Liability Noncurrent Other liabilities Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 7) Commitments And Contingencies Stockholders’ equity Stockholders Equity [Abstract] Preferred stock; $0.0001 par value; 10,000 shares authorized, and no shares issued and outstanding at December 31, 2019 and December 31, 2018 Preferred Stock Value Common stock; $0.0001 par value; 100,000 shares authorized at December 31, 2019 and December 31, 2018; 36,992 and 36,120 shares issued and outstanding at December 31, 2019 and December 31, 2018, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred stock, shares issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Interest income from licencing. Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] License and royalty [Member] License And Service [Member] Other [Member] Product And Service Other [Member] Statement [Line Items] Statement [Line Items] Revenues Revenues [Abstract] Revenues Revenue From Contract With Customer Excluding Assessed Tax Operating Expenses Costs And Expenses [Abstract] Cost of revenues Cost Of Goods And Services Sold Research and development Research And Development Expense General and administrative General And Administrative Expense Other operating expenses (income) Other Operating Income Expense Net Total operating expenses Costs And Expenses Income (loss) from operations Operating Income Loss Other Income Nonoperating Income Expense [Abstract] Interest income from licensing Interest Income From Licencing Investment income Investment Income Net Total other income Nonoperating Income Expense Income (loss) before income taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Income Tax Benefit (Expense) Income Tax Expense Benefit Net income (loss) Net Income Loss Other Comprehensive Income (Loss) Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Unrealized gain (loss) on available-for-sale securities, net Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax Total other comprehensive income (loss) Other Comprehensive Income Loss Net Of Tax Comprehensive income (loss) Comprehensive Income Net Of Tax Net income (loss) applicable to common stockholders Net Income Loss Available To Common Stockholders Basic Net income (loss) per share: Earnings Per Share Basic And Diluted [Abstract] Basic Earnings Per Share Basic Diluted Earnings Per Share Diluted Weighted-average common shares outstanding: Weighted Average Number Of Shares Outstanding [Abstract] Basic Weighted Average Number Of Shares Outstanding Basic Diluted Weighted Average Number Of Diluted Shares Outstanding Vesting of Restricted Stock Units Shares Vesting of restricted stock units Statement Of Stockholders Equity [Abstract] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock [Member] Common Stock [Member] Additional paid in capital [Member] Additional Paid In Capital [Member] Accumulated Other Comprehensive Income (Loss) [Member] Accumulated Other Comprehensive Income [Member] Accumulated Deficit [Member] Retained Earnings [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] ASU 2014-09 [Member] Accounting Standards Update201409 [Member] ASU 2016-02 [Member] Accounting Standards Update201602 [Member] ASU 2018-02 [Member] Accounting Standards Update201802 [Member] Balances Balances (Shares) Shares Outstanding Adoption of ASU 2014-09 (Topic 606) New Accounting Pronouncement Or Change In Accounting Principle Effect Of Adoption Quantification Issuance of common stock upon public offering, net of transaction costs Stock Issued During Period Value New Issues Issuance of common stock upon public offering, net of transaction costs, Shares Stock Issued During Period Shares New Issues Vesting of restricted stock units Vesting Of Restricted Stock Units Vesting of restricted stock units, Shares Vesting Of Restricted Stock Units Shares Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options, Shares Stock Issued During Period Shares Stock Options Exercised Issuance of common stock under employee stock purchase plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common stock under employee stock purchase plan, shares Stock Issued During Period Shares Employee Stock Purchase Plans Stock-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Unrealized loss on available-for-sale securities, net Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax Net income (loss) Balances Balances (Shares) Transaction costs associated with stock issuance. Issuance of Stock, transaction costs Transaction Costs Associated With Stock Issuance Imputed interest income from licensing. Non-cash consideration received for licenses granted operating activity. Operating lease right- of-use assets. Operating lease liabilities. Increase decrease in deferred rent payable. Proceeds from issuances of common stock net of underwriting discounts and commissions. Noncash or part noncash assets acquired under financing obligation. Statement Of Cash Flows [Abstract] Cash flows from operating activities Net Cash Provided By Used In Operating Activities [Abstract] Net income (loss) Profit Loss Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Stock-based compensation expense Share Based Compensation Net amortization of premiums and accretion of discounts on marketable debt securities Accretion Amortization Of Discounts And Premiums Investments Depreciation and amortization Depreciation And Amortization Net realized losses (gains) on sales and maturities of marketable securities Available For Sale Securities Gross Realized Gain Loss Net Imputed interest income from licensing Imputed Interest Income From Licensing Unrealized gains on marketable equity securities Available For Sale Equity Securities Gross Unrealized Gain Non-cash consideration received for licenses granted Non Cash Consideration Received For Licenses Granted Operating Activity Other non-cash adjustments Other Noncash Income Expense Changes in operating assets and liabilities Increase Decrease In Operating Capital [Abstract] Accounts receivable Increase Decrease In Accounts Receivable Prepaid expenses Increase Decrease In Prepaid Expense Other current assets Increase Decrease In Other Current Assets Operating lease right-of-use assets Increase Decrease In Operating Lease Right Of Use Assets Other assets Increase Decrease In Other Noncurrent Assets Accounts payable Increase Decrease In Accounts Payable Trade Accrued expenses and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Deferred revenue Increase Decrease In Deferred Revenue Operating lease liabilities Increase Decrease In Operating Lease Liabilities Deferred rent Increase Decrease In Deferred Rent Payable Other liabilities Increase Decrease In Other Operating Liabilities Net cash provided by (used in) operating activities Net Cash Provided By Used In Operating Activities Cash flows from investing activities Net Cash Provided By Used In Investing Activities [Abstract] Purchases of marketable securities Payments To Acquire Marketable Securities Maturities of marketable securities Proceeds From Sale And Maturity Of Marketable Securities Sales of marketable securities Proceeds From Sale And Maturity Of Available For Sale Securities Purchases of property and equipment Payments To Acquire Property Plant And Equipment Net cash provided by (used in) investing activities Net Cash Provided By Used In Investing Activities Cash flows from financing activities Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from exercise of stock options Proceeds From Stock Options Exercised Proceeds from issuance of common stock under employee stock purchase plan Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Proceeds from public offerings of common stock, net of underwriting discounts and commissions Proceeds From Issuances Of Common Stock Net Of Underwriting Discounts And Commissions Issuance costs for public offerings of common stock Payments Of Stock Issuance Costs Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Net increase (decrease) in cash and cash equivalents and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect Cash and cash equivalents and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents [Abstract] Beginning of period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations End of period Supplemental cash flow information Supplemental Cash Flow Information [Abstract] Cash paid for income taxes Income Taxes Paid Supplemental disclosures of non-cash investing and financing activities Noncash Investing And Financing Items [Abstract] Additions to property and equipment through accounts payable and accrued expenses Capital Expenditures Incurred But Not Yet Paid Assets acquired under financing lease obligation Noncash Or Part Noncash Assets Acquired Under Financing Obligation Non-cash consideration received for licenses granted Noncash Or Part Noncash Divestiture Amount Of Consideration Received1 Organization Consolidation And Presentation Of Financial Statements [Abstract] Nature of Business Nature Of Operations Accounting Policies [Abstract] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Investments Debt And Equity Securities [Abstract] Marketable Securities Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Property Plant And Equipment [Abstract] Property and Equipment, Net Property Plant And Equipment Disclosure [Text Block] Leases [Abstract] Leases Leases Of Lessee Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Equity [Abstract] Capitalization Stockholders Equity Note Disclosure [Text Block] License agreement revenue recognition. License Agreement Revenue Recognition [Abstract] License Agreement Revenue Recognition [Abstract] License and Royalty Revenue License Agreement Revenue Recognition [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Postemployment Benefits [Abstract] Retirement Plan Postemployment Benefits Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Related Party Transactions [Abstract] Related Party Transactions Related Party Transactions Disclosure [Text Block] Earnings Per Share [Abstract] Net Income (Loss) Per Share Earnings Per Share [Text Block] Payables And Accruals [Abstract] Supplemental Disclosures Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block] Quarterly Financial Information Disclosure [Abstract] Selected Quarterly Financial Information (Unaudited) Quarterly Financial Information [Text Block] Basis of Presentation and Principles of Consolidation Basis Of Accounting Policy Policy [Text Block] Foreign Currency Transactions Foreign Currency Transactions And Translations Policy [Text Block] Use of Estimates Use Of Estimates Reclassifications Prior Period Reclassification Adjustment Description Segment and Geographical Information Segment Reporting Policy Policy [Text Block] Cash and Cash Equivalents Cash And Cash Equivalents Policy [Text Block] Restricted Cash Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy Marketable Securities Marketable Securities Policy Concentrations of Credit Risk and Off-balance Sheet Risk Concentration Risk Credit Risk Accounts Receivable Receivables Policy [Text Block] Leases Lessee Leases Policy [Text Block] Property and Equipment Property Plant And Equipment Policy [Text Block] Impairment of Long-lived Assets Impairment Or Disposal Of Long Lived Assets Policy [Text Block] Non-marketable equity securities. Non-marketable Equity Securities Non Marketable Equity Securities Policy [Text Block] Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Revenue Recognition Revenue Recognition Policy [Text Block] Cost of Revenues Cost Of Sales Policy [Text Block] Research and Development Expense Research And Development Expense Policy Collaborative Arrangements Collaborative Arrangement Accounting Policy Stock-based Compensation Share Based Compensation Option And Incentive Plans Policy Income Taxes Income Tax Policy [Text Block] Net Income (Loss) Per Share Earnings Per Share Policy [Text Block] Comprehensive Income (Loss) Comprehensive Income Policy Policy [Text Block] Recent Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Schedule of cash and cash equivalents and restricted cash. Summary of Reconciliation of Cash and Cash Equivalents and Restricted Cash Schedule Of Cash And Cash Equivalents And Restricted Cash Table [Text Block] Schedule of Revenue or accounts receivable by Major Customers. Schedule of Revenue or Accounts Receivable by Major Customers Schedule Of Revenue Or Accounts Receivable By Major Customers Table [Text Block] Schedule of useful lives of assets. Summary of Estimated Useful Lives of Assets Schedule Of Useful Lives Of Assets Table [Text Block] Summary of Company Marketable Securities Debt Securities Available For Sale Table [Text Block] Summary of Fair Values and Unrealized Losses of Marketable Securities Held by the Company in an Unrealized Loss Position for Less Than 12 months and 12 Months or Greater Debt Securities Available For Sale Unrealized Loss Position Fair Value Table [Text Block] Schedule of Fair Value of Cash Equivalents and Marketable Securities Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block] Schedule of Property and Equipment Property Plant And Equipment [Text Block] Summary of lease costs and supplemental cash flow information of operating leases. Summary of Lease Costs and Supplemental Cash Flow Information of Operating Leases Summary Of Lease Costs And Supplemental Cash Flow Information Of Operating Leases Table [Text Block] Schedule of lessee operating lease weighted-average remaining lease term and weighted-average discount rate. Weighted-Average Remaining Lease Term and Weighted-Average Discount Rate of Operating Leases Schedule Of Lessee Operating Lease Weighted Average Remaining Lease Term And Weighted Average Discount Rate Reconciliation of Undiscounted Future Minimum Lease Payments Remaining Under 9800 Medical Center Drive Lease and Other Operating Leases Lessee Operating Lease Liability Maturity Table [Text Block] Schedule of Future Minimum Lease Payments Under Topic 840 for 9800 Medical Center Drive Lease and Other Operating Leases Schedule Of Future Minimum Rental Payments For Operating Leases Table [Text Block] Related Party Related Party Transactions By Related Party [Axis] Related Party Related Party [Domain] The Trustees of the University of Pennsylvania [Member] The Trustees of the University of Pennsylvania [Member] Trustees Of The University Of Pennsylvania [Member] Glaxo Smith Kline LLC. GlaxoSmithKline LLC [Member] Glaxo Smith Kline L L C [Member] Summary of Expenses Incurred by Company Schedule Of Related Party Transactions Table [Text Block] Schedule of Reserved Shares of Common Stock for Future Issuance Schedule Of Stock By Class [Text Block] Summary of changes in receivables and contract assets and contract liabilities. Summary of Changes in Balances of Receivables, Contract Assets and Contract Liabilities Summary Of Changes In Receivables And Contract Assets And Contract Liabilities Table [Text Block] Schedule Of License Revenue [Table Text Block] Schedule of License Revenue Schedule Of License Revenue Table [Text Block] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Two Thousand Fourteen And Two Thousand Fifteen Equity Incentive Plan [Member] 2014 and 2015 Equity Incentive Plan [Member] Two Thousand Fourteen And Two Thousand Fifteen Equity Incentive Plan [Member] Stock-Based Compensation Expense by Award Type Disclosure Of Share Based Compensation Arrangements By Share Based Payment Award [Text Block] Stock-Based Compensation Expense Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block] Summary of Stock Option Activity Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Schedule of Fair Value of Options Granted on Weighted-Average Assumptions Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Summary of Unvested RSUs Activity Under 2015 Plan Schedule Of Nonvested Restricted Stock Units Activity Table [Text Block] Components of Income (Loss) Before Income Taxes Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block] Components of the Provision For Income Tax Expense (Benefit) Schedule Of Components Of Income Tax Expense Benefit Table [Text Block] Schedule of Reconciliation of Effective Income Tax Expense (Benefit) Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block] Components of Net Deferred Tax Assets Schedule Of Deferred Tax Assets And Liabilities Table [Text Block] Computations of Basic and Diluted Net Income (Loss) Per Share Schedule Of Earnings Per Share Basic And Diluted Table [Text Block] Schedules for Computation of Diluted Weighted-Average Shares Outstanding Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Schedules of Accrued Expenses and Other Current Liabilities Schedule Of Accounts Payable And Accrued Liabilities Table [Text Block] Quarterly Financial Information Schedule Of Quarterly Financial Information Table [Text Block] Cash, cash equivalents and marketable securities Cash Cash Equivalents And Short Term Investments Significant Accounting Policies. Significant Accounting Policies. Significant Accounting Policies [Table] Significant Accounting Policies [Table] Concentration Risk Type Concentration Risk By Type [Axis] Concentration Risk Type Concentration Risk Type [Domain] Customer Concentration Risk [Member] Customer Concentration Risk [Member] Geographical Statement Geographical [Axis] Geographical Segment Geographical [Domain] United States [Member] UNITED STATES Concentration Risk Benchmark Concentration Risk By Benchmark [Axis] Concentration Risk Benchmark Concentration Risk Benchmark [Domain] Revenue [Member] Sales Revenue Net [Member] Restatement Restatement [Axis] Restatement Restatement [Domain] Restatement Adjustment [Member] Restatement Adjustment [Member] Name of Property Real Estate And Accumulated Depreciation Description Of Property [Axis] Name of Property Real Estate And Accumulated Depreciation Name Of Property [Domain] Nine Thousand Eight Hundred Medical Center Drive. 9800 Medical Center Drive Lease [Member] Nine Thousand Eight Hundred Medical Center Drive [Member] Statistical Measurement Range [Axis] Statistical Measurement Range [Member] Maximum [Member] Maximum [Member] Minimum [Member] Minimum [Member] Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Number of operating segments Number Of Operating Segments Concentration risk percentage Concentration Risk Percentage1 Total cash and cash equivalents and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Schedule Of Entity Wide Revenue By Major Customers By Reporting Segments [Table] Schedule Of Entity Wide Revenue By Major Customers By Reporting Segments [Table] Accounts Receivable Accounts Receivable [Member] Customer Major Customers [Axis] Customer Name Of Major Customer [Domain] Customer A. Customer A [Member] Customer A [Member] Customer B. Customer B [Member] Customer B [Member] Customer C. Customer C [Member] Customer C [Member] Customer D. Customer D [Member] Customer D [Member] Entity Wide Revenue Major Customer [Line Items] Entity Wide Revenue Major Customer [Line Items] Allowance for doubtful accounts receivable Allowance For Doubtful Accounts Receivable Schedule Of Property Plant And Equipment [Table] Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment, Type Property Plant And Equipment By Type [Axis] Property, Plant and Equipment, Type Property Plant And Equipment Type [Domain] Computer equipment and software. Computer Equipment and Software [Member] Computer Equipment And Software [Member] Lab Equipment [Member] Equipment [Member] Furniture and Fixtures [Member] Furniture And Fixtures [Member] Leasehold Improvements [Member] Leasehold Improvements [Member] Property Plant And Equipment [Line Items] Property Plant And Equipment [Line Items] Property plant and equipment estimated useful lives Property Plant And Equipment Useful Life Property plant and equipment estimated useful lives Property Plant And Equipment Estimated Useful Lives Impairment losses Asset Impairment Charges Percentage of ownership interest Equity Method Investment Ownership Percentage Accrued interest or penalties related to uncertain tax positions Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued Unrecognized tax benefits Unrecognized Tax Benefits Income Tax Penalties And Interest Expense Deferred rent liabilities current and noncurrent. Prepaid expenses, other current assets and other assets. Operating lease liabilities Operating Lease Liability Current and noncurrent deferred rent liabilities Deferred Rent Liabilities Current And Noncurrent Prepaid expenses, other current assets and other assets Prepaid Expenses Other Current Assets And Other Assets Financing lease obligation Capital Lease Obligations Amount of increase (decrease) in accumulated other comprehensive income (AOCI) for reclassification to retained earnings of tax effect from remeasurement of deferred tax pursuant to Tax Cuts and Jobs Act. Reclassification of stranded tax effects of unrealized gains and losses on available-for-sale securities from accumulated other comprehensive income (loss) to accumulated deficit Tax Cuts And Jobs Act Reclassification From A O C I To Retained Earnings Tax Effect Schedule Of Available For Sale Securities [Table] Schedule Of Available For Sale Securities [Table] Investment Type Investment Type [Axis] Investments Investment Type Categorization [Member] U.S. Government and Federal Agency Securities [Member] U S Government Corporations And Agencies Securities [Member] Certificates of Deposit [Member] Certificates Of Deposit [Member] Corporate Bonds [Member] Corporate Bond Securities [Member] Equity Securities [Member] Equity Securities [Member] Schedule Of Available For Sale Securities [Line Items] Schedule Of Available For Sale Securities [Line Items] Amortized Cost / Cost Available For Sale Debt Securities Amortized Cost Basis Unrealized Gains Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax Unrealized Losses Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax Fair Value Available For Sale Securities Debt Securities Available for sale debt securities remaining maturities greater than three years. Income Statement Location Income Statement Location [Axis] Income Statement Location Income Statement Location [Domain] Investment Income [Member] Investment Income [Member] Collateral Collateral [Axis] Collateral Collateral [Domain] Available for sale debt securities remaining maturities greater than three years Available For Sale Debt Securities Remaining Maturities Greater Than Three Years Unrealized gains (losses) on available-for-sale debt securities, before tax Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Before Tax Unrealized gains (losses) on available-for-sale debt securities, income tax expense Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax Net realized gains (losses) available for sale securities Debt Securities Available For Sale Realized Gain Loss Less than 12 Months, Fair Value Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months Less than 12 Months, Unrealized Losses Debt Securities Available For Sale Continuous Unrealized Loss Position Less Than12 Months Accumulated Loss 12 Months or Greater, Fair Value Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer 12 Months or Greater, Unrealized Losses Debt Securities Available For Sale Continuous Unrealized Loss Position12 Months Or Longer Accumulated Loss Total, Fair Value Debt Securities Available For Sale Unrealized Loss Position Total, Unrealized Losses Debt Securities Available For Sale Unrealized Loss Position Accumulated Loss Less than 12 Months, Fair Value Available For Sale Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value 12 Months or Greater, Fair Value Available For Sale Securities Continuous Unrealized Loss Position Twelve Months Or Longer Fair Value Total, Fair Value Available For Sale Securities Continuous Unrealized Loss Position Fair Value Number of investment grade fixed income debt security Debt Securities Available For Sale Unrealized Loss Position Number Of Positions Other-than-temporary impaired Other Than Temporary Impairment Loss Debt Securities Available For Sale Carrying value as of the balance sheet date of equity securities which are non marketable. Non-marketable equity securities, carrying value Non Marketable Equity Securities Marketable securities, unrealized gain Marketable Securities Unrealized Gain Loss Marketable securities, realized gain Marketable Securities Realized Gain Loss Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table] Fair Value Hierarchy and NAV Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy and NAV Fair Value Measurements Fair Value Hierarchy [Domain] Quoted Prices in Active Markets (Level 1) [Member] Fair Value Inputs Level1 [Member] Significant Other Observable Inputs (Level 2) [Member] Fair Value Inputs Level2 [Member] Significant Unobservable Inputs (Level 3) [Member] Fair Value Inputs Level3 [Member] Cash and Cash Equivalents Cash And Cash Equivalents [Axis] Cash and Cash Equivalents Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member] Money Market Mutual Funds [Member] Money Market Funds [Member] Asset Class Fair Value By Asset Class [Axis] Asset Class Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Cash Equivalents [Member] Cash Equivalents [Member] U.S. Government and Federal Agency Securities [Member] U S Government Agencies Debt Securities [Member] Financial Instrument Financial Instrument [Axis] Financial Instruments Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Cash equivalents and marketable securities. Cash Equivalents and Marketable Securities [Member] Cash Equivalents And Marketable Securities [Member] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items] Cash equivalents: Cash And Cash Equivalents [Abstract] Total cash equivalents Cash And Cash Equivalents Fair Value Disclosure Marketable securities: Marketable Securities [Abstract] Total cash equivalents and marketable securities Assets Fair Value Disclosure Fair value hierarchy level 1 to level 2 transfers amount Fair Value Assets Level1 To Level2 Transfers Amount Fair value hierarchy level 2 to level 1 transfers amount Fair Value Assets Level2 To Level1 Transfers Amount Remeasurements or impairment losses on non-marketable equity securities. Non-marketable equity securities had carrying value. Non-marketable equity securities Non Marketable Equity Securities Carrying Value Remeasurements or impairment losses on non-marketable equity securities Remeasurements Or Impairment Losses On Non Marketable Equity Securities Computer Equipment and Software [Member] Computer Equipment [Member] Construction in Progress [Member] Construction In Progress [Member] Total property and equipment Property Plant And Equipment Gross Accumulated depreciation and amortization Accumulated Depreciation Depletion And Amortization Property Plant And Equipment Property and equipment, net Depreciation or amortization expense Lease expiration term. Tenant improvement allowance to be received. Minimum required lease term to use optional termination of lease. Percentage of early termination fee. Term of required base rent to be paid as termination fee. Lessee, operating lease, periodic payment term, after the commencement. Lessee, operating lease, lease not yet commenced, additional area leased. Lessee, operating lease, frequency of periodic payment. Other Commitments [Table] Other Commitments [Table] Rockville, Maryland [Member] MOLDOVA Nine thousand seven hundred twelve Medical Center Drive. 9712 Medical Center Drive [Member] Nine Thousand Seven Hundred Twelve Medical Center Drive [Member] Rockville, Maryland [Member] MARYLAND Nine thousand six hundred Blackwell Road. 9600 Blackwell Road [Member] Nine Thousand Six Hundred Blackwell Road [Member] 400 Madison lease. 400 Madison Avenue [Member] Four Hundred Madison Lease [Member] 400 Madison Lease [Member] NEW YORK Lease amendment. Lease Amendment Lease Amendment [Member] Maryland and New York. Rockville, Maryland [Member] Maryland And New York [Member] Other Commitments [Line Items] Other Commitments [Line Items] Lease Expiration Term Lease Expiration Term Construction completion, description Lessee Operating Lease Lease Not Yet Commenced Description Tenant improvement allowance to be received Tenant Improvement Allowance To Be Received Lease not yet commenced, option to extend the lease Lessee Operating Lease Lease Not Yet Commenced Existence Of Option To Extend Lease not yet commenced, additional lease term Lessee Operating Lease Lease Not Yet Commenced Renewal Term1 Lease not yet commenced, option to terminate the lease Lessee Operating Lease Lease Not Yet Commenced Existence Of Option To Terminate Lease not yet commenced, option to terminate the lease, description Lessee Operating Lease Lease Not Yet Commenced Option To Terminate Minimum release term for option to terminate Minimum Required Lease Term To Use Optional Termination Of Lease Percentage of early termination fee Percentage Of Early Termination Fee Term of required base rent to be paid as termination fee Term Of Required Base Rent To Be Paid As Termination Fee Frequency of periodic payment Lessee Operating Lease Frequency Of Periodic Payment Periodic payment term, from the delivery of leased premises Lessee Operating Lease Periodic Payment Term After The Commencement Letters of credit Letters Of Credit Outstanding Amount Number of square feet to be constructed Lessee Operating Lease Lease Not Yet Commenced Additional Area Leased Financing lease obligation Lease commenced date. Lease term commenced date Lease Commenced Date Lease term Lessee Operating Lease Description Operating lease, existence of option to extend the lease Lessee Operating Lease Existence Of Option To Extend Additional lease term under option to extend Lessee Operating Lease Renewal Term Tenant improvement allowance received Payments For Proceeds From Tenant Allowance Required period to terminate lease after commencement period. Lease expiration date Lease Expiration Date1 Required period to terminate lease after commencement period Required Period To Terminate Lease After Commencement Period Operating lease commencement year. Operating leases commencement year Operating Lease Commencement Year Operating lease expiration year. Operating lease expiration year Operating Lease Expiration Year Decrease in right-of-use assets Operating lease expiration year1 Operating lease expiration year Operating Lease Expiration Year1 Operating lease cost Operating Lease Cost Variable lease cost Variable Lease Cost Total lease cost Lease Cost Cash paid for amounts included in operating lease liabilities Operating Lease Payments Right-of-use assets acquired through operating lease liabilities Right Of Use Asset Obtained In Exchange For Operating Lease Liability Weighted-average remaining lease term (years) Operating Lease Weighted Average Remaining Lease Term1 Weighted-average discount rate Operating Lease Weighted Average Discount Rate Percent Lessee Lease Description [Table] Lessee Lease Description [Table] Other properties held under operating leases. Other Operating leases [Member] Other Properties Held Under Operating Leases [Member] Lessee Lease Description [Line Items] Lessee Lease Description [Line Items] Undiscounted future minimum lease payments: Operating Lease Liabilities Payments Due [Abstract] 2020 Lessee Operating Lease Liability Payments Due Next Twelve Months 2021 Lessee Operating Lease Liability Payments Due Year Two 2022 Lessee Operating Lease Liability Payments Due Year Three 2023 Lessee Operating Lease Liability Payments Due Year Four 2024 Lessee Operating Lease Liability Payments Due Year Five Thereafter Lessee Operating Lease Liability Payments Due After Year Five Total undiscounted future minimum lease payments Lessee Operating Lease Liability Payments Due Amount representing imputed interest Lessee Operating Lease Liability Undiscounted Excess Amount Total operating lease liabilities Current portion of operating lease liabilities Operating lease liabilities, non-current Collaborative Arrangement and Arrangement Other than Collaborative Type Of Arrangement [Axis] Collaborative Arrangement and Arrangement Other than Collaborative Arrangements And Nonarrangement Transactions [Member] Other operating leases. Other Operating leases [Member] Other Operating Leases [Member] 2019 Operating Leases Future Minimum Payments Remainder Of Fiscal Year 2020 Operating Leases Future Minimum Payments Due In Two Years 2021 Operating Leases Future Minimum Payments Due In Three Years 2022 Operating Leases Future Minimum Payments Due In Four Years 2023 Operating Leases Future Minimum Payments Due In Five Years Thereafter Operating Leases Future Minimum Payments Due Thereafter Total minimum lease payments Operating Leases Future Minimum Payments Due Additional rent charges Operating Leases Rent Expense Net Upfront fee payable. University of Pennsylvania. University of Pennsylvania [Member] University Of Pennsylvania [Member] Neurimmune Neurimmune AG [Member] Neurimmune [Member] Clearside Biomedical, Inc. Clearside Biomedical Inc. [Member] Clearside Biomedical Inc [Member] Upfront fee, milestone fees Upfront Fee Payable Related party transaction expenses (revenue) from​ transactions​ with related​ party. License fees. License Fees [Member] License Fees [Member] Related Party Transaction Related Party Transaction [Axis] Related Party Transaction Related Party Transaction [Domain] Royalties on net sales of licensed products. Royalties On Net Sales Of Licensed Products [Member] Royalties On Net Sales Of Licensed Products [Member] Other costs of revenue. Other Costs Of Revenue [Member] Other Costs Of Revenue [Member] Total cost of revenues. Cost of Revenues [Member] Total Cost Of Revenues [Member] Research and Development [Member] Research And Development Expense [Member] General and Administrative [Member] General And Administrative Expense [Member] Total related party transaction expense Related Party Transaction Expenses Revenue From Transactions With Related Party Accrued expenses Accrued Liabilities Current Milestone payment obligation. Milestone payment obligation Milestone Payment Obligation Cost Of Revenue [Abstract] Cost Of Revenue [Abstract] Period for sharing of research and development cost. Percentage of partnership in collaboration. Period for sharing of research and development cost Period For Sharing Of Research And Development Cost Percentage of partnership in collaboration Percentage Of Partnership In Collaboration Payment against excercise of license option. Payments against exercise of license option Payment Against Excercise Of License Option Claims paid to date related to indemnification issues Loss Contingency Damages Paid Value Accruals or expenses related to indemnification issues Loss Contingency Accrual Provision Capitalization Longterm Debt And Equity [Abstract] Schedule Of Capitalization [Table] Schedule Of Capitalization [Table] Sale of Stock Subsidiary Sale Of Stock [Axis] Sale of Stock Sale Of Stock Name Of Transaction [Domain] Public offering. Public Offering [Member] Public Offering [Member] Overallotment Option [Member] Over Allotment Option [Member] Schedule of Capitalization [Line Items] Schedule Of Capitalization [Line Items] Number of shares issued to during period Stock issuance price per share Shares Issued Price Per Share Net proceeds from issuance of common stock Proceeds From Issuance Of Common Stock Employee Stock Purchase Plan [Member] Employee Stock [Member] Award Type Award Type [Axis] Award Type Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Incentive Plan [Member] Equity Incentive Plans [Member] Equity Incentive Plan [Member] Reserved common shares Common Stock Capital Shares Reserved For Future Issuance Number of development partnered product candidates. Number of commercial product candidates. License revenue. License revenue. License Revenue [Table] License Revenue [Table] NAV technology platform. N A V Technology Platform [Member] N A V Technology Platform [Member] Zolgensma Royalties . Zolgensma Royalties [Member] Zolgensma Royalties [Member] License [Member] License [Member] License agreement. License Agreement [Member] License Agreement [Member] March 2014 License Agreement. March 2014 License Agreement [Member] March Two Zero One Four License Agreement [Member] AveXis, Inc. AveXis, Inc. [Member] Ave Xis Incorporation [Member] January 2018 Amendment Agreement. January 2018 Amendment Agreement [Member] January Two Zero One Eight Amendment Agreement [Member] First Anniversary. First Anniversary [Member] First Anniversary [Member] Second Anniversary. Second Anniversary [Member] Second Anniversary [Member] Research and Development Arrangement, Contract to Perform for Others, Type Research And Development Arrangement Contract To Perform For Others By Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type Research And Development Arrangement Contract To Perform For Others Type [Domain] Sales based milestones. Share-based Milestone [Member] Sales Based Milestones [Member] June two thousand seventeen license agreement. June 2017 License Agreement [Member] June Two Thousand Seventeen License Agreement [Member] Abeona Therapeutics Inc Abeona Therapeutics Inc. [Member] Abeona Therapeutics Incorporation [Member] November two thousand eighteen due. November 2018 [Member] November Two Thousand Eighteen Due [Member] November two thousand nineteen due. November 2019 [Member] November Two Thousand Nineteen Due [Member] November two thousand twenty due. November 2020 [Member] November Two Thousand Twenty Due [Member] November two thousand twenty one due. November 2021 [Member] November Two Thousand Twenty One Due [Member] November two thousand twenty two due. November 2022 [Member] November Two Thousand Twenty Two Due [Member] November two thousand twenty three due. November 2023 [Member] November Two Thousand Twenty Three Due [Member] November two thousand twenty four due. November 2024 [Member] November Two Thousand Twenty Four Due [Member] April Two Thousand Twenty [Member]. April 2020 [Member] April Two Thousand Twenty [Member] November two thousand eighteen license agreement. November 2018 License Agreement [Member] November Two Thousand Eighteen License Agreement [Member] Third anniversary. Third Anniversary Third Anniversary [Member] License Revenue [Line Items] License Revenue [Line Items] Number of development partnered product candidates Number Of Development Partnered Product Candidates Number of commercial product candidates Number Of Commercial Product Candidates Milestone fee payments upon commencement of clinical trials. Milestone fee payments upon submission of regulatory approval filings. Milestone fee payments upon approval of commercial products. Milestone fee payments upon achievement of specified sales targets. Milestone fee payments upon submission preclinical filings. Milestone payment upon commencement of clinical trials in humans Milestone Fee Payments Upon Commencement Of Clinical Trials Milestone fee upon submission of preclinical regulatory filings Milestone Fee Payments Upon Submission Preclinical Filings Milestone payment upon submission of regulatory approval filings Milestone Fee Payments Upon Submission Of Regulatory Approval Filings Milestone payment upon approval of commercial products by regulatory agencies Milestone Fee Payments Upon Approval Of Commercial Products Milestone payment upon achievement of specified sales targets for licensed products Milestone Fee Payments Upon Achievement Of Specified Sales Targets Receivables and contract assets. Deductions related to accounts receivable. Additions related to accounts receivable. Receivables and contract assets: Receivables And Contract Assets [Abstract] Accounts receivable, current and non-current, Balance at Beginning of Period Accounts Receivable Net Additions Related To Accounts Receivable Additions Related To Accounts Receivable Deductions Related To Accounts Receivable Deductions Related To Accounts Receivable Accounts receivable, current and non-current, Balance at End of Period Deductions related to contract with customer asset. Additions related to contract with customer assets. Contract assets, Balance at Beginning of Period Contract With Customer Asset Net Current Additions Related To Contract With Customer Assets Additions Related To Contract With Customer Assets Deductions Related To Contract With Customer Asset Deductions Related To Contract With Customer Asset Contract assets, Balance at End of Period Deductions related to contract with customer liability. Additions related to contract with customer liability. Contract liabilities: Contract With Customer Liability [Abstract] Deferred revenue, current and non-current, Balance at Beginning of Period Contract With Customer Liability Additions Related To Contract With Customer Liability Additions Related To Contract With Customer Liability Deductions Related To Contract With Customer Liability Deductions Related To Contract With Customer Liability Deferred revenue, current and non-current, Balance at End of Period Accounts receivable Deferred revenue, current and non-current Licenses revenue License revenue Contract With Customer Performance Obligation Satisfied In Previous Period Impairment losses on receivables or contract assets Capitalized Contract Cost Impairment Loss Total current and non-current accounts receivable Billed to customers Billed Contract Receivables Billable to customers in future periods Unbilled Contracts Receivable Upfront license fee paid. Milestone fee payments upon achievement of various development and commercialization. Up-front fee paid Upfront License Fee Paid Milestone fee payments upon achievement of various development and commercialization Milestone Fee Payments Upon Achievement Of Various Development And Commercialization License agreement period. License agreement period License Agreement Period License agreement amendment date. License agreement amendment date License Agreement Amendment Date License fees. Milestone payments. Unpaid milestone payments. License fee License Fees Milestone payment Milestone Payments Sales-based milestone payment unpaid in the event of change of control Unpaid Milestone Payments License fees received Proceeds From License Fees Received Transaction price of license. Payments for remaining development milestones. Increase in transaction price of license. Transaction price of license Transaction Price Of License Payments for remaining development milestones Payments For Remaining Development Milestones Increase in transaction price of license Increase In Transaction Price Of License Sales-based milestone payment exclude transaction price. Consideration payment due period one. Consideration payment due period two. Transaction price description Revenue Information Used To Determine Transaction Price Sales-based milestone payment exclude transaction price Sales Based Milestone Payment Exclude Transaction Price Payments due from related party Due From Related Parties Consideration payment due period one Consideration Payment Due Period One Consideration payment due period two Consideration Payment Due Period Two Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Start Date [Axis] Revenue, remaining performance obligation, expected timing of satisfaction, period Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Period1 Total license and royalty revenue Revenue From Contract With Customer Including Assessed Tax Accounts receivable Accounts Receivable Gross Accounts receivable, current Accounts receivable, non -current Accounts Receivable Gross Noncurrent Upfront and annual license fee receivable. Upfront and annual payments receivable upon termination of license agreement prior to expiration. Sales based milestone payments receivable. Remaining unpaid portion of upfront and annual fees. Increase in upfront and annual license fee receivable. Increase in upfront and annual fees Increase In Upfront And Annual License Fee Receivable Up-front and anuual fees Upfront And Annual License Fee Receivable Upfront and annual fees upon termination of license agreement Upfront And Annual Payments Receivable Upon Termination Of License Agreement Prior To Expiration Remaining unpaid portion of upfront and annual fees Remaining Unpaid Portion Of Upfront And Annual Fees Sales-based milestone payments Sales Based Milestone Payments Receivable License agreement initial contract term. License agreement initial contract term License Agreement Initial Contract Term Upfront license fee received. Upfront payment received Upfront License Fee Received License agreement financing term. License agreement financing term License Agreement Financing Term Share based compensation arrangement increase in number of shares reserved for issuance percentage under plan. Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Two Thousand And Fifteen Equity Incentive Plan [Member] 2015 Equity Incentive Plan [Member] Two Thousand And Fifteen Equity Incentive Plan [Member] Subsequent Event Type Subsequent Event Type [Axis] Subsequent Event Type Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent Event [Member] Non-employee stock option. Non-Employee Stock Option [Member] Non Employee Stock Option [Member] Restricted Stock Units (RSUs) Restricted Stock Units R S U [Member] 2015 Employee Stock Purchase Plan. 2015 Employee Stock Purchase Plan [Member] Two Thousand Fifteen Employee Stock Purchase Plan [Member] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Percentage of annual increase in number of shares available for future issuance Share Based Compensation Arrangement Increase In Number Of Shares Reserved For Issuance Percentage Under Plan Common stock shares authorized for issuance Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized Shares available for future grants Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Additional shares to be issued Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized Stock options expiration date Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period Stock options vesting period Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1 Stock plan expiration date. Stock plan expiration date Stock Plan Expiration Date Stock Option [Member] Employee Stock Option [Member] Stock-based compensation expense Allocated Share Based Compensation Expense Unrecognized stock-based compensation expense Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Unrecognized stock-based compensation, weighted-average period Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1 Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares [Roll Forward] Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward Shares Outstanding, Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Shares, Granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Shares, Exercised Shares, Cancelled or forfeited Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Shares Outstanding, Ending Balance Shares, Exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number Shares, Vested and expected to vest Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward Weighted-average Exercise Price Outstanding, Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Weighted-average Exercise Price, Granted Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Weighted-average Exercise Price, Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Weighted-average Exercise Price, Cancelled or forfeited Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price Weighted-average Exercise Price, Outstanding, Ending Balance Weighted-average Exercise Price, Exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price Weighted-average Exercise Price, Vested and expected to vest Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract] Weighted-average Remaining Contractual Life (Years) Outstanding Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2 Weighted-average Remaining Contractual Life (Years), Exercisable Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1 Weighted-average Remaining Contractual Life (Years), Vested and expected to vest Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1 Aggregate Intrinsic Value Outstanding Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value Aggregate Intrinsic Value, Exercisable Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1 Aggregate Intrinsic Value, Vested and expected to vest Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value Weighted-average fair values of options granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value Total intrinsic value of options exercised Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract] Expected volatility Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Expected term (in years) Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1 Risk-free interest rate Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Expected dividend yield Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Unvested stock options outstanding Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Number Of Shares Shares Unvested, Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number Shares, Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Shares, Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Shares, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period Shares Unvested, Ending Balance Weighted-average Grant Date Fair Value, Unvested Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Weighted-average Grant Date Fair Value, Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value Weighted-average Grant Date Fair Value, Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value Weighted-average Grant Date Fair Value, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value Weighted-average Grant Date Fair Value, Unvested Ending Balance Total intrinsic values vested Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Vested Restricted stock units vested Share based compensation arrangement by share based payment award percentage of outstanding stock minimum. Share-based compensation arrangement by share-based payment award, description Share Based Compensation Arrangement By Share Based Payment Award Description Share-based compensation arrangement by share-based payment award, percentage of outstanding stock minimum Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Minimum Common stock shares issued to participants Share Based Compensation Arrangement By Share Based Payment Award Shares Issued In Period Compensation And Retirement Disclosure [Abstract] Employer matching contribution expense Defined Contribution Plan Employer Discretionary Contribution Amount United States Income Loss From Continuing Operations Before Income Taxes Domestic Foreign Income Loss From Continuing Operations Before Income Taxes Foreign Current: Current Federal State And Local Tax Expense Benefit [Abstract] Federal Current Federal Tax Expense Benefit State Current State And Local Tax Expense Benefit Foreign Current Foreign Tax Expense Benefit Total current Current Income Tax Expense Benefit Deferred: Deferred Federal State And Local Tax Expense Benefit [Abstract] Federal Deferred Federal Income Tax Expense Benefit State Deferred State And Local Income Tax Expense Benefit Foreign Deferred Foreign Income Tax Expense Benefit Total deferred Deferred Income Tax Expense Benefit Total income tax expense (benefit) Tax Cuts and Jobs Act of 2017, limitation of net operating loss deductions as percentage of current year taxable income. Income tax disclosure. Income tax disclosure. Income Tax Disclosure [Table] Income Tax Disclosure [Table] Income Tax Authority Income Tax Authority [Axis] Income Tax Authority Income Tax Authority [Domain] Domestic Country [Member] Domestic Country [Member] U. S State Tax Authority [Member] State And Local Jurisdiction [Member] Income Tax Disclosure [Line Items] Income Tax Disclosure [Line Items] Federal statutory income tax rate, percent Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate Tax Cuts and Jobs Act of 2017, limitation of net operating losses deductions as percentage of current year taxable income Tax Cuts And Jobs Act Of2017 Limitation Of Net Operating Loss Deductions As Percentage Of Current Year Taxable Income Amount of reasonable estimate for income tax expense for remeasurement of deferred tax asset and valuation allowance from change in tax rate pursuant to Tax Cuts and Jobs Act for which accounting for tax effect is incomplete. Tax Cuts and Jobs Act of 2017, incomplete accounting change in tax rate deferred tax asset and valuation allowance provisional income tax expense Tax Cuts And Jobs Act Of2017 Incomplete Accounting Change In Tax Rate Deferred Tax Asset And Valuation Allowance Provisional Income Tax Expense Federal income tax expense (benefit) at statutory rate Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate State income tax expense (benefit), net of federal tax effect Income Tax Reconciliation State And Local Income Taxes Research and development credits Income Tax Reconciliation Tax Credits Research Stock-based compensation expense for incentive stock options and employee stock purchase plan Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost Other non-deductible expenses and reconciling items Income Tax Reconciliation Nondeductible Expense Other Change in corporate tax rates Income Tax Reconciliation Change In Enacted Tax Rate Change in valuation allowance Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance Deferred tax assets increase in asset value upon conversion. Deferred tax assets tax deferred expense compensation and benefits non-qualified share based compensation cost. Deferred tax assets lease liability. Deferred tax assets depreciation. Deferred tax liabilities right-of-use assets. Deferred tax assets: Deferred Tax Assets Net [Abstract] Net operating loss carryforwards Deferred Tax Assets Operating Loss Carryforwards Research and development tax credits Deferred Tax Assets Tax Credit Carryforwards Research Step-up in assets upon conversion to C-corporation Deferred Tax Assets Increase In Asset Value Upon Conversion Stock-based compensation expense for non-qualified stock options and restricted stock units Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Non Qualified Share Based Compensation Cost Unrealized losses on marketable securities Deferred Tax Assets Unrealized Losses On Availablefor Sale Securities Gross Lease liabilities Deferred Tax Assets Lease Liability Deferred rent Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Deferred Rent Depreciation Deferred Tax Assets Depreciation Accruals and other Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Other Total deferred tax assets before valuation allowance Deferred Tax Assets Gross Valuation allowance Deferred Tax Assets Valuation Allowance Total deferred tax assets Deferred Tax Assets Net Deferred tax liabilities: Components Of Deferred Tax Liabilities [Abstract] Unrealized gains on marketable securities Deferred Tax Liabilities Unrealized Gains On Trading Securities Right-of-use assets Deferred Tax Liabilities Right Of Use Assets Depreciation Deferred Tax Liabilities Property Plant And Equipment Other Deferred Tax Liabilities Other Total deferred tax liabilities Deferred Income Tax Liabilities Net deferred tax assets Deferred Tax Assets Liabilities Net Cumulative loss position period. Cumulative loss position period Cumulative Loss Position Period Increase (decrease) in valuation allowance Valuation Allowance Deferred Tax Asset Change In Amount Operating loss carryforwards expiration year. Operating loss carryforwards Operating Loss Carryforwards Operating Loss Carryforwards Expiration Year Operating Loss Carryforwards Expiration Year Tax credit carryforward, expiration year. Research and development and orphan drug tax credit carryforwards Tax credit carryforwards, expiration year Tax Credit Carryforward Expiration Year Reserve for uncertain tax positions placed against credit carryforwards Unrecognized Tax Benefits Reserve for uncertain tax positions placed against qualified expenses Cumulative changes in ownership interest percentage. Ownership interest change period. Cumulative changes in ownership Interest percentage threshold, subject to annual limitation of NOL and tax credit carryforwards Cumulative Changes In Ownership Interest Percentage Ownership interest change period Ownership Interest Change Period Schedule Of Related Party Transactions By Related Party [Table] Schedule Of Related Party Transactions By Related Party [Table] FOXKISER limited liability partnership. FOXKISER,LLP [Member] F O X K I S E R Limited Liability Partnership [Member] Finite-Lived Intangible Assets by Major Class Finite Lived Intangible Assets By Major Class [Axis] Finite-Lived Intangible Assets, Major Class Name Finite Lived Intangible Assets Major Class Name [Domain] Service Agreements [Member] Service Agreements [Member] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related party transaction expense Related Party Transaction Expenses From Transactions With Related Party Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Employee stock purchase plan. Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Basic net income (loss) per share: Earnings Per Share Basic [Abstract] Shares used in computation: Earnings Per Share Basic Other Disclosures [Abstract] Weighted-average common shares outstanding Basic net income (loss) per share Diluted net income (loss) per share: Earnings Per Share Diluted [Abstract] Net income (loss) applicable to common stockholders Net Income Loss Available To Common Stockholders Diluted Shares used in computation: Earnings Per Share Diluted Other Disclosures [Abstract] Weighted-average diluted common shares Diluted net income (loss) per share Stock Options Issued and Outstanding [Member] Unvested Restricted Stock Units Outstanding [Member] Anti-dilutive securities excluded from computation of diluted weighted average shares outstanding Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Accrued external research and development expenses. Accrued sublicense fees and royalties on reagent sales. Accrued external general and administrative expenses, Accrued purchases of property and equipment. Accrued personnel costs Employee Related Liabilities Current Accrued external research and development expenses Accrued External Research And Development Expenses Accrued sublicense fees and royalties Accrued Sublicense Fees And Royalties On Reagent Sales Accrued external general and administrative expenses Accrued External General And Administrative Expenses Accrued purchases of property and equipment Accrued Purchases Of Property And Equipment Accrued income taxes payable Accrued Income Taxes Current Other accrued expenses and current liabilities Other Accrued Liabilities Current Accrued expenses and other current liabilities Cost of goods and services sold net of goods credit. Total revenues Cost of revenues Cost Of Goods And Services Sold Net Of Goods Credit Research and development expense General and administrative expense Total operating expenses